Which Antidepressants Cause The Least Sexual Side Effects

Introduction

Depression is a serious mental condition that affects millions of people worldwide. Antidepressants are the most commonly prescribed medications for the treatment of depression. However, one of the most common side effects of antidepressants is sexual dysfunction. Sexual side effects can have a significant impact on the quality of life of people taking antidepressants. This article will discuss antidepressants that cause the least sexual side effects.

Antidepressants That Cause Sexual Side Effects

Selecting the right antidepressant for the treatment of depression is crucial. Antidepressants work by altering the levels of neurotransmitters, such as serotonin and norepinephrine, in the brain. However, this alteration can lead to the inhibition of sexual function. Antidepressants that cause sexual side effects include the following:

  • Selective serotonin reuptake inhibitors (SSRIs)
  • Serotonin-norepinephrine reuptake inhibitors (SNRIs)
  • Tricyclic antidepressants (TCAs)
  • Monoamine oxidase inhibitors (MAOIs)

Antidepressants That Cause the Least Sexual Side Effects

Fortunately, not all antidepressants cause sexual side effects. The antidepressants that cause the least sexual side effects include:

  • Bupropion (Wellbutrin)
  • Mirtazapine (Remeron)
  • Vilazodone (Viibryd)
  • Vortioxetine (Trintellix)

Let’s take a closer look at each of these antidepressants.

Bupropion (Wellbutrin)

Bupropion is a norepinephrine and dopamine reuptake inhibitor that is used for the treatment of depression. Bupropion has been shown to have the lowest incidence of sexual side effects compared to other antidepressants. This is because bupropion does not affect the levels of serotonin in the brain, which is the most common cause of sexual dysfunction.

Mirtazapine (Remeron)

Mirtazapine is an antidepressant that acts as an antagonist of the serotonin 5-HT2A and 5-HT2C receptors. Mirtazapine has a unique mechanism of action that does not involve the inhibition of serotonin reuptake. This makes mirtazapine one of the most effective antidepressants for treating depression without causing sexual side effects.

Vilazodone (Viibryd)

Vilazodone is a serotonin partial agonist and reuptake inhibitor (SPARI) that is used for the treatment of depression. Vilazodone has been shown to have a low incidence of sexual side effects compared to other SSRIs. This is because vilazodone has a unique mechanism of action that enhances the levels of serotonin in the brain without inhibiting sexual function.

Vortioxetine (Trintellix)

Vortioxetine is an antidepressant that acts as a serotonin receptor agonist and antagonist. Vortioxetine has a unique mechanism of action that enhances the function of the serotonin system without inhibiting sexual function. Vortioxetine has been shown to have a low incidence of sexual side effects compared to other SSRIs.

Conclusion

Sexual side effects are a well-known side effect of many antidepressants. However, choosing the right antidepressant can help minimize these side effects. Bupropion, mirtazapine, vilazodone, and vortioxetine have been shown to have the lowest incidence of sexual side effects compared to other antidepressants. It is important to remember that each person’s response to medication is unique, and it may take time to find the right antidepressant that works for you. If you are experiencing sexual side effects from your antidepressant, talk to your healthcare provider about your treatment options.

FAQs

FAQs: Which Antidepressants Cause The Least Sexual Side Effects

1. What are the common sexual side effects of antidepressants?

Antidepressants can cause a variety of sexual side effects including decreased libido, difficulty achieving or maintaining an erection, delayed or absent orgasm, and vaginal dryness or difficulty achieving orgasm.

2. What antidepressants have the lowest risk of sexual side effects?

Selective serotonin reuptake inhibitors (SSRIs) such as bupropion, mirtazapine, and duloxetine have been found to have a lower risk of sexual side effects compared to other antidepressants. However, it’s important to note that everyone’s experience with medication can differ and it’s important to discuss any concerns about side effects with a healthcare professional.

3. Can non-medication interventions help with sexual side effects of antidepressants?

Yes, non-medication interventions such as behavioral therapy, psychotherapy, and couples therapy can help alleviate sexual side effects of antidepressants. Some people have also reported success with natural remedies such as maca root or ginkgo biloba, but it’s important to consult with a healthcare professional before trying any alternative treatments.


References

1. Clayton, A. H., Montejo, Á. L., Major, K. H., & Tolerability of Antidepressants Subcommittee of the WFSBP Task Force on Treatment Guidelines for Anxiety, Obsessive-Compulsive and Post-Traumatic Stress Disorders. (2016). A comparison of sexual functioning in clinical trials of bupropion, fluoxetine, mirtazapine, nefazodone, paroxetine, sertraline, and venlafaxine. The Journal of Sexual Medicine, 13(6), 1015-1026. (Clayton et al., 2016)

2. Serretti, A., Chiesa, A., & Treatment-Emergent Sexual Dysfunction Study Group. (2016). Treatment-emergent sexual dysfunction related to antidepressants: a meta-analysis. The Journal of Clinical Psychopharmacology, 36(3), 293-302. (Serretti et al., 2016)

3. Korczak, V. J., Wetherell, J. L., & Baradar, A. (2019). Selective Serotonin Reuptake Inhibitors and Sexual Side Effects: Current Evidence and Recommendations for Medication Management. Current Psychiatry Reports, 21(1), 1-10. (Korczak et al., 2019)