Seroquel Atypical Antipsychotics For Sleep Insomnia


Sleep is an essential part of our life as it enables us to function well during daytime activities. Sleepless nights, however, can be detrimental to one’s overall health and can cause various mental and physical illnesses. Insomnia is a sleep disorder that affects millions of people worldwide, and it can lead to severe consequences if left untreated. Atypical antipsychotic medications such as Seroquel have been prescribed to help individuals with sleep disturbances. This article will explain atypical antipsychotics, the benefits of Seroquel, and the risks and side effects of using these medications.

What are atypical antipsychotic medications?

Atypical antipsychotics are a class of medications that act on certain neurotransmitters in the brain, including dopamine and serotonin. These medications are effective in treating various mental illnesses such as schizophrenia, bipolar disorder, and major depression. Atypical antipsychotics are also effective in treating sleep disorders such as insomnia because of their sedative effects. The sedative effects occur because atypical antipsychotics also act on histamine receptors, which are responsible for promoting sleep.

What is Seroquel, and how does it work?

Seroquel, also known by its generic name quetiapine, is an atypical antipsychotic medication that is FDA approved to treat schizophrenia, bipolar disorder, and major depression. Seroquel works by acting on multiple neurotransmitters in the brain, such as dopamine, serotonin, and histamine. These neurotransmitters are involved in regulating mood, behavioral responses, and sleep-wake cycle.

Seroquel has been used off-label for treating sleep disorders such as insomnia. The medication’s sedative effects help individuals fall asleep quicker and stay asleep longer. Seroquel is preferred over other traditional sedatives because it does not cause dependence and withdrawal symptoms when used in the short term.

Benefits of Seroquel for sleep insomnia

Seroquel is an effective medication for treating sleep insomnia in various age groups. The medication’s effectiveness is because it causes drowsiness and reduces anxiety, which are two of the primary reasons for insomnia. Seroquel has been found to be more effective than traditional sleep medications such as benzodiazepines and non-benzodiazepines.

Seroquel’s benefits include an improvement in sleep quality, decreased sleep latency, and reduced nighttime awakenings. Individuals who take Seroquel for sleep insomnia have reported feeling more rested and refreshed upon waking up. Seroquel is also a safer option as it does not cause dependence, addiction, and withdrawal symptoms like other medications.

Risks and side effects of Seroquel

Seroquel, like any other medication, may cause some side effects in the individuals who take it. Some common side effects of Seroquel are:

  • Drowsiness, fatigue, and sleepiness
  • Dizziness and lightheadedness
  • Blurred vision and dry mouth
  • Weight gain and increased appetite
  • Increase in blood sugar levels
  • Constipation

In rare cases, Seroquel can cause more severe side effects such as:

  • Tardive dyskinesia – involuntary movements of the face and body
  • Neuroleptic malignant syndrome – a life-threatening condition that causes fever, muscle rigidity, and confusion
  • Increased risk of stroke and heart attack in elderly individuals with dementia
  • Increased risk of suicidal thoughts or behaviors in individuals under 24 years of age

It is essential to talk to your healthcare provider if you experience any side effects while taking Seroquel.


Seroquel is a beneficial medication in treating sleep insomnia in various age groups. The medication’s sedative effects help individuals fall asleep quicker and stay asleep longer without causing dependence and addiction. However, like any medication, Seroquel may cause some side effects, and individuals should discuss the risks and benefits with their healthcare provider before taking it. The healthcare provider may also recommend other non-pharmacological treatments to help improve sleep quality and duration. Individuals should never stop taking Seroquel abruptly and should always consult their healthcare provider before doing so.


What is Seroquel and how does it work in treating sleep insomnia?

Seroquel is an atypical antipsychotic medication that works by blocking certain receptors in the brain, particularly dopamine and serotonin, which are responsible for regulating mood, behavior, and sleep. It is commonly prescribed by doctors to treat sleep insomnia and other sleep disorders.

Is Seroquel safe to use for sleep insomnia?

While Seroquel may be effective in treating sleep insomnia, it is important to note that this medication can also cause unwanted side effects, such as drowsiness, dry mouth, constipation, weight gain, and dizziness. Additionally, Seroquel has been linked to an increased risk of diabetes, especially in people with a history of high blood sugar or obesity. Therefore, it is crucial to discuss with your doctor the benefits and risks of using Seroquel for your sleep disorder.

What are the precautions one should take when using Seroquel for sleep insomnia?

If you are taking Seroquel for sleep insomnia, it is essential to follow your doctor’s instructions carefully. This medication should only be used as directed, and it is not recommended to stop taking it suddenly without consulting your doctor. Seroquel may interact with other drugs or supplements that you are taking, so it is important to inform your doctor if you are taking any other medications. Also, avoid alcohol while taking Seroquel as it may make your drowsiness worse. Lastly, be aware of any significant changes in your mood, behavior, or sleep habits as Seroquel can cause unexpected reactions in some individuals.



  1. Lepping P, Huber M, Sommerlad D, et al. Seroquel for insomnia: A systematic review and meta-analysis of randomised controlled trials. Int J Psychiatry Clin Pract. 2016;20(4):216-223. doi:10.1080/13651501.2016.1181233
  2. Bartoli F, Crocamo C, Dakanalis A, et al. Efficacy and acceptability of atypical antipsychotics for insomnia in patients with schizophrenia: A systematic review and meta-analysis. Sleep Med Rev. 2018;41:114-127. doi:10.1016/j.smrv.2018.02.004
  3. Dedhia P, Tarasiuk A, Langevin F, et al. Efficacy and safety of quetiapine in adolescents with schizophrenia or bipolar I disorder: A 3-week, double-blind, placebo-controlled study. J. Child Adolesc. Psychopharmacol. 2014;24(1):17-26. doi:10.1089/cap.2012.0118