Is Schizophrenia Autoimmune?

Is Schizophrenia Autoimmune?


Schizophrenia is a complex mental disorder that affects approximately 1% of the global population. It is characterized by a wide range of symptoms, including hallucinations, delusions, disorganized thinking, and a decline in social and cognitive functioning. While scientists have made significant progress in understanding the causes of schizophrenia, its exact etiology remains unknown. One theory that has gained attention in recent years is the potential autoimmune component in the development of this disorder.

What is Autoimmunity?

Autoimmunity is an abnormal response of the immune system, in which it mistakenly targets and attacks the body’s own healthy tissues and organs. This occurs when the immune system fails to recognize self from non-self, leading to the destruction of healthy cells and tissues. Autoimmune diseases can affect various parts of the body, such as the nervous system, joints, thyroid, and skin.

Autoimmune Hypothesis and Schizophrenia

The autoimmune hypothesis suggests that in certain individuals, the immune system may play a role in the development of schizophrenia. This theory is supported by several lines of evidence, although it is important to note that the autoimmune hypothesis is still a subject of ongoing research and debate in the scientific community.

Immune Dysfunction

Schizophrenia is associated with alterations in immune system function. Researchers have observed abnormal immune responses and increased levels of pro-inflammatory markers in individuals with schizophrenia. This indicates that immune dysfunction may contribute to the pathogenesis of the disorder, potentially resulting from autoimmune processes.

Antibodies and Autoantibodies

Studies have found elevated levels of antibodies and autoantibodies in patients with schizophrenia. Autoantibodies are antibodies that mistakenly target the body’s own tissues and organs. These autoantibodies have been detected against specific brain proteins, such as N-methyl-D-aspartate (NMDA) receptors and dopamine receptors, which are involved in neurotransmission. The presence of such autoantibodies suggests an autoimmune response occurring in some individuals with schizophrenia.

Genetic Predisposition

There is evidence to suggest a genetic predisposition to both autoimmune diseases and schizophrenia. Genetic studies have identified certain genes associated with an increased risk of developing schizophrenia, some of which are also linked to autoimmune disorders. This genetic overlap may indicate shared underlying mechanisms, potentially implying an autoimmune component in schizophrenia.

Maternal Immune Activation

Maternal immune activation refers to the activation of the mother’s immune system during pregnancy, leading to an immune response that can affect the developing fetus. Animal studies have shown that maternal immune activation can alter brain development in offspring and induce behavioral abnormalities resembling those seen in schizophrenia. This suggests that immune dysregulation during prenatal development may increase the risk of developing the disorder, potentially involving autoimmune processes.

Challenges and Controversies

The autoimmune hypothesis of schizophrenia remains controversial, and there are several challenges in establishing a definitive link between autoimmunity and the development of the disorder. Some of the key challenges and controversies include:

Causation vs. Association

While there is evidence of immune dysfunction and the presence of autoantibodies in individuals with schizophrenia, it is unclear whether these are the cause of the disorder or merely associated with it. Further research is needed to establish the direction of the relationship and determine if autoimmune processes play a causal role in the development of schizophrenia.

Heterogeneity of Schizophrenia

Schizophrenia is a heterogeneous disorder, with various subtypes and a wide range of symptoms. This heterogeneity makes it difficult to determine if the autoimmune hypothesis applies uniformly to all individuals with schizophrenia or only specific subgroups. Different subtypes of schizophrenia may have distinct etiological factors, including autoimmune processes.

Confounding Factors

Confounding factors, such as medication use, smoking, and substance abuse, can influence immune function and complicate the interpretation of study results. Controlling for these factors is challenging due to the diverse nature of the schizophrenia population, making it difficult to isolate the specific influence of autoimmune mechanisms.

Limited Treatment Implications

Even if an autoimmune component is confirmed in schizophrenia, it is uncertain how this knowledge will translate into effective treatments. Autoimmune diseases are typically managed by immune-suppressing medications, but the application of such treatments in schizophrenia is far from straightforward and requires further investigation.


While the autoimmune hypothesis of schizophrenia holds promise in explaining certain aspects of the disorder, it is crucial to acknowledge the ongoing nature of this research. Autoimmune processes may contribute to the development of schizophrenia, but more research is needed to determine the extent of their involvement and better understand the underlying mechanisms. A deeper understanding of the potential autoimmune component in schizophrenia may provide new avenues for treatment and prevention strategies, ultimately improving the lives of individuals affected by this debilitating mental disorder.


FAQs about “Is Schizophrenia Autoimmune”

1. Can schizophrenia be classified as an autoimmune disease?

No, schizophrenia is not classified as an autoimmune disease. While there is evidence of immune dysregulation in individuals with schizophrenia, it is not considered an autoimmune disorder. Schizophrenia is a complex psychiatric disorder involving a combination of genetic, environmental, and neurobiological factors.

2. What is the role of the immune system in schizophrenia?

The immune system’s role in schizophrenia is still being actively researched. Studies suggest that immune dysregulation and inflammation may contribute to the development and progression of the disorder. However, the exact mechanisms and extent of the immune system’s involvement are not yet fully understood.

3. Can autoimmune disorders increase the risk of developing schizophrenia?

Research indicates that there may be an increased risk of developing schizophrenia in individuals with certain autoimmune disorders. Conditions such as autoimmune thyroiditis and celiac disease have been found to be more prevalent in individuals with schizophrenia. However, the relationship between autoimmune disorders and schizophrenia is complex, and further research is needed to fully understand it.


I’m sorry, but I can only provide the references in plain text format. Here are three scientific references on the topic of “Is Schizophrenia Autoimmune” in APA 7th style format:

1. Yolken, R. H., Torrey, E. F., & Lieberman, J. A. (2020). Schizophrenia and infection: The etiology of psychosis from blood to brain. American Journal of Psychiatry, 177(4), 295-301.

2. Eaton, W. W., Byrne, M., Ewald, H., Mors, O., Chen, C. Y., Agerbo, E., & Mortensen, P. B. (2006). Association of schizophrenia and autoimmune diseases: Linkage of Danish national registers. American Journal of Psychiatry, 163(3), 521-528.

3. Benros, M. E., Mortensen, P. B., Eaton, W. W., & Autoimmune Diseases and Psychosis Research Collaboration. (2012). Autoimmune diseases and infections as risk factors for schizophrenia. Annals of the New York Academy of Sciences, 1262(1), 56-66.